Quick Takeaways:
- Elanco’s Credelio Quattro (lotilaner, moxidectin, praziquantel, pyrantel) demonstrated faster tick kill than Simparica Trio and NexGard Plus in Parasites & Vectors. It was the only product to significantly reduce black-legged ticks within 8 hours and maintained this speed through Day 28, with no significant performance drop-off.
- Lotilaner, the active ingredient in Credelio Quattro, showed the fastest initial kill against lone star ticks, killing them within 12 hours and sustaining its advantage throughout the dosing interval. At Day 28, Credelio Quattro outperformed Simparica Trio (12 hours) and NexGard Plus (24 hours). The product is FDA-approved to help prevent Lyme disease in dogs.
- The studies evaluated tick-kill speed at 4, 8, 12, 24 and 48 hours after treatment and reinfestation. Black-legged ticks transmit Lyme disease and anaplasmosis, while lone star ticks can transmit pathogens and are linked to alpha-gal syndrome. Credelio Quattro protects against both species, with rapid kill important as disease transmission risk rises with attachment time.
Why It Matters?
Credelio Quattro appears to have a clear speed-of-kill advantage over Simparica Trio and NexGard Plus, with the studies showing faster and more sustained tick kill through the full monthly dosing interval. That matters because quicker tick death lowers the window for disease transmission, which strengthens Credelio Quattro’s appeal for dogs at risk of Lyme disease and other tick-borne infections.
Source: Elanco
